The crash happened at about 5:12 a.m. in the southbound lanes of I-55 at Black Road in Joliet, police said.
ISP confirmed it was a deadly crash. No information about the victims was available.
All lanes reopened at approximately 11:21 a.m.
Traffic was being diverted off I-55 southbound at U.S. Route 30.
Video shows at least three vehicles left with damage in the crash.
One appeared to have caught fire and veered off the highway.
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