The crash happened at about 5:21 a.m. at Cicero Avenue, police said.
Police said the crash involved a box truck and a passenger car.
In video obtained by ABC7, a vehicle was seen upside down with extensive damage off the expressway.
At least one passenger was taken to an area hospital. Their condition was not released.
By 7:12 a.m. all lanes reopened.
No further information was available.