The crash happened at about 12:53 p.m. on the northbound lanes of I-55 at California, police said.
A truck tractor dump trailer hauling gravel rolled over, ISP said.
Two people were taken to area hospitals with injuries, police said.
All northbound lanes were shut down at Damen for cleanup until approximately 3:35 p.m., ISP said.
The left lane and left shoulder remained closed.
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