The crash happened at about 3:10 a.m. in the 7700-block of S. Cicero Avenue near the Scottsdale neighborhood.
A woman was driving a Nissan Altima northbound when she lost control of the car and crashed into a pole, police said.
The 41-year-old woman was taken to the hospital with multiple injuries where she later died.
A 35-year-old man was the passenger in the car. He was taken to the hospital with minor injuries and police said he is expected to be okay.
Chicago police are investigating.