The explosion happened in the afternoon at a building in the 2200 block of Central Avenue in Cicero, officials said.
No one was inside the building at the time of the explosion, but one family has been displaced from their home.
A neighboring building caught fire due to the explosion and another building was also damaged, officials.
Cicero police and fire have responded to the scene and are investigating the cause of the explosion.
No further information was immediately available.