A Cicero spokesperson said the single-vehicle crash happened at 15th Street and Cicero Avenue around 11:15 p.m.
A person inside the vehicle was transported to a local hospital in serious condition, the spokesperson said.
Authorities are investigating the possibility that the injured person suffered a medical emergency before the crash.
Northbound Cicero Avenue was temporarily closed as officials investigated.
Authorities did not immediately provide further information about the crash.