The person was struck around 1:46 a.m. on the northbound lanes of I-94 near 82nd Street in the Chatham neighborhood, according to Illinois State Police.
A White Volkswagen was driving northbound when it struck a pedestrian walking on the Dan Ryan Expressway.
The pedestrian died at the scene.
All northbound lanes were between 79th and 83rd are shut down for hours as police investigated.
All lanes reopened by 5:13 a.m.
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No other information was available.