Mundelein police said officers and members of the fire department responded to a crash involving a Suzuki motorcycle and a Honda SUV near Route 45 and Route 83 around 5:25 p.m.
The motorcyclist, a 34-year-old man, was ejected, police said. He was pronounced dead on the scene, and his name was not immediately released.
Police said the intersection was shut down but is expected to reopen around 8:30 p.m.
The Mundelein Police Department, the Lake County Major Crash Assistance Team, and the Lake County Coroner's Office are investigating.
Authorities did not immediately provide further information.