ISP said the crash happened on Interstate 57 southbound, north of Sauk Trail, just after 6:30 a.m. That's near Richton Park.
A semi was reportedly parking on the right shoulder of I-57 when a sedan drove off the roadway and struck it, ISP said.
ISP said the sedan's driver was extricated from the vehicle and taken to a local hospital with injuries.
Chopper 7 was over the scene.
All lanes of I-57 southbound were temporarily shut down between U.S. 30 and Sauk Trail.
All lanes reopened by 11:10 a.m.
Authorities did not immediately provide further information.