The crash occurred in the southbound lanes of the Kennedy Expressway near Belmont Avenue.
Police said the semi-truck carrying meat overturned. The driver was transported to a hospital, but was later pronounced dead, police said.
He was later identified as 62-year-old Darryl King by the Cook County Medical Examiner's Office.
LIVE TRAFFIC: Check out the latest conditions on our live traffic map
Lanes in both directions were blocked as crews investigate the crash. All lanes were back open by 7:30 a.m.
The crash blocked several lanes of traffic. Further details were not immediately available.