The crash occurred in the southbound lanes just north of Steger Road in Sauk Village about 7:45 a.m.
Illinois State Police said a car crashed into the back of a semitrailer, and the driver of the car died on the scene.
All southbound lanes were closed to traffic until they reopened at around 11:30 a.m.
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Chopper 7 was over the scene about 9:45 a.m.
The car appeared to have front-end damage, and drove into a field after the crash.