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FBI spokeswoman Wendy Osborn told The Indianapolis Star on Thursday that federal agents assisted the Bloomington Police Department in investigative work in Morgan County. In a news release, Bloomington police confirmed their involvement in the "active and ongoing investigation" into Spierer's disappearance.
Authorities declined to name the exact location on Thursday.
Crews with WISH-TV in Indianapolis reported seeing agents focused Thursday on a home and barn in the Martinsville area, including sifting through dirt.
Spierer's disappearance generated national headlines. The 20-year-old Greenburgh, New York, woman vanished in June 2011, after a night out with friends in Bloomington, Indiana.
Bloomington police have said they received hundreds of tips in the investigation.
The Associated Press contributed to this report.