Chopper 7 was over the scene as dozens of firefighters battled the blazed in Cicero near 29th Street and 51st Avenue.
A spokesperson for the city of Cicero said two people died as a result of the fire.
It is unknown which house the victims were from.
Officials have not released any information regarding the victims.
It is unknown what time the fire started. or what caused the fire.
Around 6 a.m. Chopper 7 captured as a second home caught fire.
2 houses engulfed in flames in Cicero
Roads in the area were still closed at 8:30 a.m. as police investigated the scene.