The local favorite is located in Concourse B near Gate B14.
Travelers will be get to enjoy its classic Chicago-style Italian beef sandwiches at the airport.
The new restaurant will be open from 7 a.m. to 8 p.m.
Mayor Brandon Johnson was in attendance at the ribbon cutting ceremony on Tuesday.
The local spot was the inspiration for the hit-show "The Bear" starring Jeremy Allen White and Ayo Edebiri.
The new restaurant is the 24th local business on display at Midway airport.
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The Original Mr. Beef opens at Chicago's Midway International Airport