Police said the shooting happened in the Gage Park neighborhood's 5100-block of South Campbell Avenue around 4:30 p.m.
A 25-year-old man suffered gunshot wounds to his chest and head, police said.
The victim was transported in critical condition to Holy Cross Hospital, where he was pronounced dead. His identity was not immediately released.
Area One detectives are investigating. Authorities did not immediately provide further information about the shooting.
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