Police say around 3 a.m., the group of 15 and 16 year olds were speeding in unincorporated Hampshire Township when the driver hit a tree off Dietrich Road.
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The 16-year-old driver was airlifted by LifeNet Helicopter to Advocate Lutheran General Hospital in Park Ridge with life-threatening injuries.
The 15-year-old front passenger was initially transported to Northwest Huntley Hospital and then airlifted to Comer Children's Hospital in Chicago with life-threatening injuries.
A 15-year-old female rear passenger was initially transported to Sherman Hospital and then transferred to Ann & Robert H. Lurie Children's Hospital in Chicago with life-threatening injuries.
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A 16-year-old female rear passenger was initially transported to Sherman Hospital and then taken Advocate Lutheran General Hospital with life-threatening injuries.
Another 15-year-old female passenger was initially transported to Northwest Huntley Hospital and then also taken to Comers Children's Hospital in Chicago with life-threatening injuries.
Authorities are investigating what led to the crash.