Illinois State Police said troopers responded to the crash on the outbound Dan Ryan Expressway just after 3 a.m.
A pedestrian was struck and taken to a local hospital, ISP said. Their condition was not immediately known.
The driver fled the scene.
The 95th Street off ramp from the outbound Interstate 94 remains shut down as police investigate.
What led up to the crash was not immediately clear.
Authorities did not immediately provide further information.
This is a developing story. Check back with ABC7 for updates.