The crash happened in the southbound lanes between Somers Road and First Street.
Multiple vehicles, including two semis, were involved. Several vehicles were involved in pileup crashes behind the semis. Both trucks caught on fire.
The Kenosha County Sheriff's Department said two people were taken to the hospital with minor injuries, but there were no serious injuries and no fatalities.
Northbound lanes reopened around 8:45 p.m. and all southbound lanes were expected to be open again by 9:30 p.m.