Troopers responded to southbound Interstate 57 near Halsted Street just after 9 p.m.
ISP said a Chevrolet Impala ran off the roadway and up the embankment before striking a tree.
The driver, a woman, died on the scene, ISP said. A man who was a passenger in the vehicle was taken to a local hospital.
The southbound lanes of I-57 were closed until about 1:50 a.m.
ISP said the investigation is ongoing and did not immediately provide further information.