ISP said the crash happened in the eastbound lanes of the Jane Addams Memorial Tollway at Meacham Road just before 1:40 p.m. That's near Schaumburg and Rolling Meadows.
The crash, which happened near a Carvana Vending Machine, involved a dump truck and a truck-tractor semi-trailer, ISP said.
Both drivers were transported to local hospitals with injuries. Their conditions were not immediately known.
Chopper 7 over crash on I-90 in northwest suburbs
The left three lanes were closed after the crash, and traffic was slowing getting by through the right lane and the shoulder.
As of 10 p.m., only one left lane remained closed for crews to fix the left concrete median barrier wall, state police said.
ISP did not immediately provide further information about the crash.