ISP said troopers responded to the two-vehicle crash on northbound Interstate 94, south of Illinois Route 120 near Gurnee, just before 5 a.m.
Two people were transported to a local hospital, ISP said.
One of those injured was later pronounced dead. Their identity was not immediately released.
ISP said three lanes are closed.
What led up to the crash was not immediately clear.
Authorities did not immediately provide further information about the crash.