ISP said troopers responded to the crash on northbound I-57 at 127th Street around 4:45 a.m. That's near the Calumet River in Blue Island.
Investigators believe a passenger vehicle and an IDOT SUV had been involved in a crash and pulled over to the left shoulder, where another vehicle struck them.
One person was pronounced dead at a local hospital, ISP said. Their identity was not immediately released.
ISP said an IDOT worker was injured and hospitalized. Their condition was not immediately known.
Two northbound lanes are closed as the accident reconstruction team investigates. Traffic is getting by on the right shoulder.
What led up to the crash was not immediately clear.
Further information was not immediately available.