The crash occurred in the eastbound lanes of I-80 near Kedzie Avenue.
Police said the semi-trailer left the roadway, went down an embankment and overturned onto Kedzie Avenue.
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Police said the driver of the semi-trailer was pronounced dead. One lane on eastbound I-80 was closed, and both directions of Kedzie Avenue under I-80 were closed, police said.
They have since reopened.
Police are investigating, and further details were not immediately available.