The crash took place at Thorndale in Itasca around 11:15 a.m., state police said.
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Chopper 7 was over the scene about noon.
The truck was crashed over the median. Several other vehicles appeared to be damaged.
At least one person was taken to a local hospital, with non-life threatening injuries.
Four eastbound and three westbound lanes of I-290 and the eastbound ramp from Route 390 to I290 are closed for the crash investigation.
It's not immediately clear what led to the crash.
Drivers are asked to seek alternate routes.
This is a developing story; check back with ABC7 Chicago for updates.