The crash occurred in the westbound lanes of I-94 at Mile Marker 29, east of Chesterton and west of Michigan City.
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Initially, the crash shut down the expressway before being cleared later Tuesday morning.
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Master Trooper Glen Fifield joined ABC7 Tuesday morning and said that Indiana State Police had responded to 31 crashes because of lake-effect snow. Fifield encourages motorists to slow down and increase following distance between vehicles.