Kianna Galvin was 17 when she went missing on May 6, 2016.
She told her family she was going to nearby Jim Hansen Park, but never returned home.
Ten years later, investigators will conduct a forensic excavation at a house in the 800-Block of Revere Road, the Kane County State's Attorney's Office said.
Investigators are targeting the home after a GPR scan that "revealed anomalies beneath the surface."
A portion of Revere Road will be closed on Thursday until the excavation is completed.
Chopper 7 was over the house at 8:30 a.m. where multiple investigation tents were seen on the driveway and in the backyard.
South Elgin Police Department and Fox Valley Major Crimes Task Force will conduct the excavation.
"Ten years have passed since Kianna disappeared, and the weight of that loss is still deeply felt by her family, her friends, and this entire community," said Kane County State's Attorney Jamie L. Mosser. "My heart remains with all who continue to carry that pain. We have not forgotten Kianna, and we remain steadfast in our commitment to seek the truth. It is my hope that renewed efforts will finally bring the answers her family deserves. I urge anyone with information, no matter how small it may seem, to come forward and contact the police."
No other information was available.