Bryant, who is originally from Lower Merion, Pennsylvania, announced on Instagram that they are expecting their fourth child.
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Bryant said he and Vanessa are beyond excited to welcome their fourth daughter, or as he wrote in the post "another #mambacita."
She will join 15-year-old Natalia, 12-year-old Gianna and 2-year-old Bianka.
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Bryant, 40, retired from the NBA in 2016 after a 20-year career with the Los Angeles Lakers. He won five NBA championships with the team.