Police responded just after 5 p.m. to a crash with injuries at 129th and Tyler, just south of Crown Point, the sheriff's office said.
When police arrived, they saw a Hyundai Santa Fe SUV had left the road, crashed into a home and rolled over, creating a hole in the house.
No one was home at the time, police said.
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The driver, a 69-year-old Cedar Lake woman, may have suffered a medical episode, which caused her to lose control of the vehicle, police said.
She was the sole occupant of the SUV.
She was taken to a hospital and stabilized.
The investigation is ongoing, police said.