The crash happened around 11:46 a.m. at the intersection of West Winchester Road and North Butterfield Road in Libertyville, police said.
An SUV, a van and a box truck were involved in the crash, Libertyville police said.
The driver of the van was taken to a local hospital, where they were later pronounced dead. Their age, gender and identity were not immediately known.
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No other injuries were initially reported.
Police continue to investigate the cause of the crash. No further information was immediately available.