The crash happened on Thursday on Route 53 near the Lisle Bible Church, video from Chopper 7 shows.
Police said two vehicles crashed, sending at least one of them off the road.
Fire officials told ABC7 that a driver came off the road and crashed into the back of a home.
Lisle police said one of the vehicles was on fire when officers arrived.
One person was taken to an area hospital, officials said. They are expected to be OK.
Chopper 7 was over the scene, where a black vehicle was seen lodged into a house.
A white van was also seen down the road with damage to the front. The bumper appeared to be ripped off and on the road.
Route 53 was closed for a time, but has since reopened.
No other information was available.