Police responded to the crash at West Jefferson Street and Airport Drive at about 6:30 p.m.
A Ford Ranger being driving by the Lombard man was driving westbound on West Jefferson Street when it struck a Jeep Grand Cherokee also driving westbound on Jefferson Street.
The Ford then struck a Tesla 3 driving westbound, then drove between the Jeep and the Tesla, swerved to the left into eastbound traffic where it struck a Pontiac Torrent head-on, police said.
The driver of the Ford was transported to Ascension St. Joseph Medical Center, where he was pronounced dead. No other injuries were reported from the crash.