It happened just before 12:30 a.m. at 43rd and Pulaski and in the Archer Heights neighborhood.
Police said a 24-year-old man was driving a silver SUV when he crashed into a black sedan being driven by the 19-year-old man.
The teen was transported to Mt. Sinai Hospital where he died.
The 24-year-old was treated at St. Anthony Hospital for a broken arm.
CPD Major Accidents is investigating the incident.