The Westmont Fire Department responded to the scene near the Westmont Train Depot just after 6:30 p.m.
A westbound BNSF commuter train struck the pedestrian, who was pronounced dead on the scene.
West Burlington Avenue west of Lincoln Street is closed, the fire department said.
Metra said trains are operating with delays.
Metra is investigating the incident.
Authorities did not immediately provide further information.