Amiirah Gholston, 3, and 6-year-old Herman Gholston were last seen on Saturday.
Police say they were last seen in the South Shore neighborhood's 7500-block of Kingston Avenue with a person named Delisa Gear. Police did not say what the relationship is between the three.
Amirah Gholston is 3-foot-7 and was last seen dressed in all blue.
Herman Gholston is 4-foot-3 and was dressed in red with black gym shoes.
Dial 911 if you have any information.