The changes are part of a settlement the team reached with the Justice Department.
Federal prosecutors had claimed that recent ball park renovations violated the Americans with Disabilities Act.
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The Cubs have agreed to remove non-compliant wheelchair spaces and replace them with spaces that have better views of the field.
In a statement, the Cubs said, "Wrigley Field is more accessible today than ever in its history and we are pleased to have come to this resolution with the Department of Justice."