The crash happened in the 7600-block of Dempster Street, Niles police said.
Video obtained by ABC7 shows a gray sedan with a broken windshield.
At about 8 a.m., all eastbound and westbound lanes were closed from Ozark St. to Ottawa Ave.
Ozark Street was closed between Dempster St. and Crain St.
All lanes reopened by 1 p.m.
Police did not say how serious the injuries were.
No other information was available.