The crash happened at about 5:47 am on the eastbound lanes of the Indiana Toll Rd at mile marker 5, near Calumet Avenue, state police said.
A Fed Ex truck and a pickup truck were involved in a crash.
Chopper 7 was over the scene; it appeared the pickup truck caught on fire.
The Fed Ex truck's load ended up the concrete wall.
Police said there were no injuries in the crash.
Eastbound lanes were temporarily closed as crews cleared the scene.