Des Plaines Police Chief William Kushner said the incident was confined to a single home and there is no danger to the community.
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Investigators combed through the suburban home Thursday night. The crime scene command van was a startling sight for neighbors.
"This is not normal for our neighborhood. It's a very quiet area," said Teresa Walsh, neighbor.
Police arrived around midday to the house on Beau Drive.
Neighbors said they saw a man being wheeled away on a gurney, another man in handcuffs and a woman who appeared distraught and left in an ambulance.
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"There was someone outside obviously needing medical attention. And the cops just started kind of swarming all over the place. It was something out of a movie," said Jennifer Winslow, neighbor.
Sources said at least one man is dead, and identified him as a male resident of the home.
"You see these neighbors. They say hi to you when you walk by, and it's like all of a sudden this happens," Walsh said.
Sources tell ABC7 Eyewitness News the man who died worked as a musician and has lived at the home for a few years. Neighbors say they've never seen police at the house in the past.