Schererville police and fire officials responded to the crash near U.S. 30 and Fountain Park Drive just before 5:30 p.m.
The driver of a 2011 Nissan was heading westbound on U.S. 30 when he struck the business, police said.
Police have not said what may have caused the driver to crash.
He was taken to a hospital, and no one else was hurt.
The South Lake County Crash Reconstruction Team is leading the investigation.
Further information was not immediately available.