Video captured by ABC7 Chicago shows as the yellow school bus is being towed with extensive damage.
The crash happened near IL-137 and US Route 41 in North Chicago at about 4:15 a.m., according to the North Chicago Fire Department.
Officials said the bus rear-ended the semi.
Four adults were taken to local hospitals with minor injuries. No children were on the bus.
The Waukegan Fire Department assisted in the response.