The semi overturned on the northbound I-65 ramp to westbound I80/94 near Lake Station, Indiana.
Chopper 7 was over the scene around 6 a.m. Video shows as crews worked to clean up the scene of the crash.
The crash was first reported around 3:30 a.m.
Indiana State Police have not released any information on what led to the crash.
Authorities said that the ramp was expected to be closed for a couple of hours as crews transferred the cattle to another semi.
The extent of the driver's injuries were not immediately known.
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