The incident happened in Schererville, at the start of the evening rush hour. Police said they got a call about a man in a semi threatening another person.
Officers found the driver on US-30, but that driver kept going onto Route 41.
Eventually, the semi hit stop sticks that police had put down and ran into multiple vehicles, including a police SUV.
Video of the aftermath was posted on the Citizen ap.
The semi driver is now in the hospital. A police investigation is ongoing.