Kankakee County sheriff's deputies and officers from neighboring agencies responded to the area of 13100 East Central Street in Pembroke Township just before midnight.
Large groups of people, who were there for two parties happening at a nearby banquet hall, were running when officers arrived.
Officers found five people who had suffered gunshot wounds.
The Kankakee County Coroner's Office said 32-year-old Edward E. Colon, of Chicago, was pronounced dead at the scene around 12:30 a.m. Saturday.
Kankakee resident Milton J. Sykes, 44, was pronounced dead at Riverside Medical Center.
What led up to the shooting was not immediately clear.
Police asked anyone with information to contact KanComm at 815-933-3324 or remain anonymous by calling CrimeStoppers at 815-93-CRIME.