The crash occurred in the 3600-block of West Marquette around 4:08 a.m. when a white caravan traveling westbound on Marquette struck a support beam of a viaduct, police said.
Police say 10-year-old Carlos Rodriguez was pronounced dead at a local hospital.
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The driver, a 32-year-old man, was hospitalized in serious condition and a 13-year-old girl was transported in stable condition.
Police are continuing to investigate.