Police responded at about 6:30 a.m. to the intersection of Belmont Avenue and George Street for the crash involving a car and an e-bike.
The 19-year-old driver of the e-bike was transported to Loyola Hospital, where he was pronounced dead, police said.
The 63-year-old man driving the car remained on the scene, police said.
The Major Crash Unit of the West Suburban Major Crimes Task Force is investigating.