The crash happened at about 10:09 p.m. in the 4500-block of W. Madison Street, police said.
A man, 26, was driving a tow truck eastbound on Madison and allegedly crashed into a CPD squad unit that was heading southbound.
Police said the crash happened at the intersection.
Two Chicago police officers were taken to an area hospital; both are expected to be OK.
The driver that allegedly crashed into police was not injured. Police said he was issued a citation.
No other information was available.