The crash happened around 7:17 p.m. near Route 120 and Greenleaf Street in Waukegan, police said.
A motorcycle was the only vehicle involved in the crash, officials said. The operator was ejected from the motorcycle during the crash.
The motorcyclist was taken to a local hospital, where he was later pronounced dead as a result of the crash.
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He was identified Wednesday by the Lake County Coroner's Office as 44-year-old Dustin Humphrey of Winthrop Harbor.
No further information about the crash was immediately available as Waukegan police continue to investigate.