Police said the shooting happened in the West Chatham neighborhood's 7900-block of South Lafayette Avenue at about 4:30 p.m.
A 30-year-old man was driving westbound on 79th Street when a sedan pulled up, and someone inside fired shots, police said.
Police said the victim suffered multiple gunshot wounds to his head and body, causing his vehicle to crash into a pole near the intersection.
The victim was transported to the University of Chicago Medical Center, where he was pronounced dead.
There is no one in custody, and Area Two detectives are investigating.
Police did not immediately provide further information.
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