The victim was identified as Antoinette Brown, of Chicago, according to the Cook County Medical Examiner's Office.
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The shooting happened at about 10:30 a.m. in the 8900 block of South Burley Avenue.
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Brown was sitting in the driver's seat of the car when someone began firing at her.
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She was shot in the head and chest and pronounced dead at the scene.
No one was immediately taken into custody.
Chicago police were investigating.