University leaders said they made the decision because of concerns over privacy, censorship and national security.
People on campus will still be able to access TikTok while using their cellular data or a Wi-Fi network not affiliated with Purdue.
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Some lawmakers are trying to ban TikTok from operating in the United States, citing concerns about privacy and ties to the Chinese government.
Many TikTok users have voiced their discontent over lawmakers moving to ban the app.